Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 9/20 | 0.48 |
| ▸ | ADA | P00813 | 1/20 | 0.43 |
| ▸ | ADK | P55263 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 10/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.35 |
| ▸ | NT5E | P21589 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18484829 | 1.00 | ADORA2A (0.48) | ADORA2AADAADKADORA3ADORA1 | |
| SCHEMBL18868168 | 0.89 | PDE4D (0.39) | ADORA2AADAADKNPC1GALR3 | |
| SCHEMBL18484832 | 0.88 | PDE4D (0.48) | ADORA2AADKNPC1GALR3S1PR4 | |
| SCHEMBL6379623 | 0.85 | ADORA2A (0.46) | ADORA2AADAADKADORA3ADORA1 | |
| SCHEMBL1738024 | 0.84 | ADORA2A (0.62) | ADORA2AADAADKADORA3ADORA1 | |
| SCHEMBL12031305 | 0.84 | ADORA2A (0.62) | ADORA2AADAADKADORA3ADORA1 | |
| SCHEMBL14470815 | 0.84 | ADORA2A (0.62) | ADORA2AADAADKADORA3ADORA1 | |
| SCHEMBL19126270 | 0.84 | ADORA2A (0.35) | ADORA2AADAADKADORA1ADORA2B | |
| SCHEMBL18484827 | 0.84 | ADORA2A (0.35) | ADORA2AADAADKADORA1ADORA2B | |
| SCHEMBL22156516 | 0.83 | ADORA2A (0.48) | ADORA2AADAADORA3ADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170253628-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE | 2017-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170253628-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | TYMP, PNP, DPYD | ADORA2A 359/4885ADA 46/4885ADK 566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.