Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 20/20 | 0.83 |
| ▸ | FLT3 | P36888 | 7/20 | 0.83 |
| ▸ | KDR | P35968 | 2/20 | 0.83 |
| ▸ | PDGFRA | P16234 | 9/20 | 0.82 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.73 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16045596 | 0.91 | CSF1R (1.00) | CSF1RFLT3KDRPDGFRAPDGFRB | |
| SCHEMBL16045621 | 0.90 | CSF1R (1.00) | CSF1RFLT3KDRPDGFRAPDGFRB | |
| SCHEMBL16047879 | 0.84 | CSF1R (1.00) | CSF1RFLT3KDRPDGFRAPDGFRB | |
| SCHEMBL16049133 | 0.84 | CSF1R (1.00) | CSF1RFLT3KDRPDGFRAPDGFRB | |
| SCHEMBL16046398 | 0.81 | CSF1R (1.00) | CSF1RFLT3KDRPDGFRAPDGFRB | |
| SCHEMBL16046187 | 0.80 | CSF1R (0.79) | CSF1RFLT3KDRPDGFRAPDGFRB | |
| SCHEMBL16046816 | 0.79 | CSF1R (0.76) | CSF1RFLT3KDRPDGFRAPDGFRB | |
| SCHEMBL16046818 | 0.79 | CSF1R (0.76) | CSF1RFLT3KDRPDGFRAPDGFRB | |
| SCHEMBL16046371 | 0.78 | CSF1R (1.00) | CSF1RFLT3KDRPDGFRAPDGFRB | |
| SCHEMBL16049098 | 0.78 | CSF1R (0.73) | CSF1RFLT3KDRPDGFRAPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968286-B1 | 2-AMINOPYRIMIDIN-6-ONES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | DECIPHERA PHARMACEUTICALS LLC (US) | 2017-09-13 | — | — | EP | claimed |