Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.47 |
| ▸ | NAAA | Q02083 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7189359 | 1.00 | EPHX1 (0.47) | EPHX1NAAAHTTALDH1A1NPC1 | |
| SCHEMBL11434425 | 0.89 | EPHX1 (0.41) | EPHX1NAAAHTTALDH1A1NPC1 | |
| SCHEMBL566591 | 0.88 | NPC1 (0.44) | EPHX1NAAAHTTALDH1A1NPC1 | |
| SCHEMBL19018658 | 0.88 | NPC1 (0.44) | EPHX1NAAAHTTALDH1A1NPC1 | |
| SCHEMBL996780 | 0.88 | NPC1 (0.44) | EPHX1NAAAHTTALDH1A1NPC1 | |
| SCHEMBL9129037 | 0.88 | NPC1 (0.44) | EPHX1NAAAHTTALDH1A1NPC1 | |
| SCHEMBL60435 | 0.88 | — | — | |
| SCHEMBL5150085 | 0.88 | NPC1 (0.44) | EPHX1NAAAHTTALDH1A1NPC1 | |
| Charcoal, Activated SCHEMBL12484130 | 0.85 | NPC1 (0.43) | EPHX1NAAAHTTALDH1A1NPC1 | |
| Ammonia Solution, Strong SCHEMBL8076859 | 0.85 | NPC1 (0.43) | EPHX1NAAAHTTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3626721-B1 | SYNTHESIS OF ESTER AND AMIDE DERIVATIVES OF BETA-LACTAM NUCLEI | BONOMI PAOLO (FR) | 2023-09-06 | — | — | EP | claimed |
| EP-3626721-A2 | SYNTHESIS OF ESTER AND AMIDE DERIVATIVES OF BETA-LACTAM NUCLEI | Bonomi, Paolo (FR) | 2020-03-25 | — | — | EP | claimed |
| EP-3426662-A1 | SYNTHESIS PROCESS OF PRECURSORS OF DERIVATIVES OF -LACTAM NUCLEI AND PRECURSORS AND DERIVATIVES THEREOF | Bonomi, Paolo (FR) | 2019-01-16 | — | — | EP | claimed |
| WO-2017153892-A1 | SYNTHESIS PROCESS OF PRECURSORS OF DERIVATIVES OF β-LACTAM NUCLEI AND PRECURSORS AND DERIVATIVES THEREOF | BONOMI PAOLO (FR) | 2017-09-14 | — | — | WO | claimed |
| EP-3426662-B1 | A SYNTHESIS PROCESS OF PRECURSORS OF DERIVATIVES OF BETA-LACTAM NUCLEI AND CORRESPONDING PRECURSORS AND DERIVATIVES. | BONOMI PAOLO (FR) | 2019-11-06 | — | — | EP | disclosed |
| US-10385068-B2 | Synthesis process of precursors of derivatives of beta-lactam nuclei and precursors and derivatives thereof | BONOMI PAOLO (FR) | 2019-08-20 | — | — | US | disclosed |
| EP-3426662-A1 | SYNTHESIS PROCESS OF PRECURSORS OF DERIVATIVES OF -LACTAM NUCLEI AND PRECURSORS AND DERIVATIVES THEREOF | Bonomi, Paolo (FR) | 2019-01-16 | — | — | EP | disclosed |
| WO-2017153892-A1 | SYNTHESIS PROCESS OF PRECURSORS OF DERIVATIVES OF β-LACTAM NUCLEI AND PRECURSORS AND DERIVATIVES THEREOF | BONOMI PAOLO (FR) | 2017-09-14 | — | — | WO | disclosed |
| WO-2017153892-A1 | SYNTHESIS PROCESS OF PRECURSORS OF DERIVATIVES OF β-LACTAM NUCLEI AND PRECURSORS AND DERIVATIVES THEREOF | BONOMI PAOLO (FR) | 2017-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385068-B2 | Synthesis process of precursors of derivatives of beta-lactam nuclei and precursors and derivatives thereof | CPSF6, CPSF1, CPS1 | EPHX1 4001/4885NAAA 84/4885HTT 4568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.