Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 20/20 | 0.79 |
| ▸ | ATR | Q13535 | 4/20 | 0.79 |
| ▸ | MTOR | P42345 | 15/20 | 0.72 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19329285 | 1.00 | ATM (0.79) | ATMATRMTORPIK3CAKCNH2 | |
| SCHEMBL19329281 | 0.89 | ATM (0.72) | ATMATRMTORPIK3CAKCNH2 | |
| SCHEMBL19329280 | 0.89 | ATM (0.72) | ATMATRMTORPIK3CAKCNH2 | |
| SCHEMBL25351294 | 0.89 | ATM (0.72) | ATMATRMTORPIK3CAKCNH2 | |
| SCHEMBL20006466 | 0.89 | ATM (0.73) | ATMATRMTORPIK3CAKCNH2 | |
| SCHEMBL17245622 | 0.89 | ATM (0.73) | ATMATRMTORPIK3CAKCNH2 | |
| SCHEMBL19329261 | 0.88 | ATM (1.00) | ATMATRMTORPIK3CAKCNH2 | |
| SCHEMBL19346437 | 0.88 | ATM (1.00) | ATMATRMTORPIK3CAKCNH2 | |
| SCHEMBL19329262 | 0.88 | ATM (1.00) | ATMATRMTORPIK3CAKCNH2 | |
| SCHEMBL18327213 | 0.86 | ATM (0.81) | ATMATRMTORPIK3CAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017153578-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-09-14 | — | — | WO | claimed |
| WO-2017153578-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-09-14 | — | — | WO | disclosed |