⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359573 | 0.84 | — | — | |
| SCHEMBL2045665 | 0.69 | — | — | |
| SCHEMBL2038910 | 0.69 | — | — | |
| SCHEMBL2041584 | 0.67 | — | — | |
| SCHEMBL2040563 | 0.65 | — | — | |
| SCHEMBL3359862 | 0.63 | — | — | |
| SCHEMBL2044235 | 0.62 | — | — | |
| SCHEMBL2044874 | 0.60 | — | — | |
| SCHEMBL19558053 | 0.60 | — | — | |
| SCHEMBL2043827 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190071399-A1 | INDOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | SYGNATURE DISCOVERY LTD (GB) | 2019-03-07 | — | — | US | claimed |
| EP-3426649-A1 | INDOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Respivert Limited (GB) | 2019-01-16 | — | — | EP | claimed |
| WO-2017153748-A1 | INDOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2017-09-14 | — | — | WO | claimed |
| US-11208381-B2 | Indole derivatives and their use as protein kinase inhibitors | RESPIVERT LIMITED (GB) | 2021-12-28 | — | — | US | disclosed |
| CN-109153666-B | Indole derivatives and their use as protein kinase inhibitors | 莱斯彼维特有限公司 | 2021-07-16 | — | — | CN | disclosed |
| US-20210114982-A1 | INDOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2021-04-22 | — | — | US | disclosed |
| US-10669235-B2 | Indole derivatives and their use as protein kinase inhibitors | RESPIVERT LIMITED (GB) | 2020-06-02 | — | — | US | disclosed |
| US-20190071399-A1 | INDOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | SYGNATURE DISCOVERY LTD (GB) | 2019-03-07 | — | — | US | disclosed |
| EP-3426649-A1 | INDOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Respivert Limited (GB) | 2019-01-16 | — | — | EP | disclosed |
| WO-2017153748-A1 | INDOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2017-09-14 | — | — | WO | disclosed |
| CN-102822170-B | Substituted N-(1H-indazol-4-yl)imidazo[1, 2-a]pyridine-3- carboxamide compounds as cFMS inhibitors | ARRAY BIOPHARMA INC | 2014-12-10 | — | — | CN | disclosed |
| CN-102822170-A | Substituted N-(1H-indazol-4-yl)imidazo[1, 2-a]pyridine-3- carboxamide compounds as cFMS inhibitors | ARRAY BIOPHARMA INC | 2012-12-12 | — | — | CN | disclosed |