Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 13/20 | 0.79 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.73 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1933243 | 0.89 | TTK (1.00) | TTKLRRK2JAK2PIK3CDPIK3CA | |
| SCHEMBL1934237 | 0.85 | TTK (0.78) | TTKLRRK2JAK2PIK3CDPIK3CA | |
| SCHEMBL12506767 | 0.82 | LRRK2 (0.81) | TTKLRRK2JAK2PIK3CDPIK3CA | |
| SCHEMBL1933136 | 0.80 | TTK (0.69) | TTKLRRK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL12507202 | 0.79 | TTK (0.79) | TTKLRRK2JAK2PIK3CDPIK3CA | |
| SCHEMBL1932188 | 0.79 | TTK (1.00) | TTKLRRK2JAK2PIK3CDPIK3CA | |
| SCHEMBL2185756 | 0.78 | TTK (0.77) | TTKLRRK2JAK2PIK3CDPIK3CA | |
| SCHEMBL12553755 | 0.78 | TTK (0.76) | TTKLRRK2JAK2PIK3CDPIK3CA | |
| SCHEMBL1932082 | 0.78 | TTK (0.79) | TTKLRRK2JAK2PIK3CDPIK3CA | |
| SCHEMBL1933539 | 0.78 | TTK (0.73) | TTKLRRK2JAK2PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507236-B1 | Triazolopyridine derivates | BAYER IP GMBH (DE) | 2014-12-17 | — | — | EP | claimed |
| US-20130121994-A1 | TRIAZOLOPYRIDINE DERIVATIVES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-16 | — | — | US | claimed |
| EP-2507236-A1 | TRIAZOLOPYRIDINE DERIVATIVES | Bayer Intellectual Property GmbH (DE) | 2012-10-10 | — | — | EP | claimed |
| EP-2343295-A1 | Triazolopyridine derivates | Bayer Schering Pharma AG (DE) | 2011-07-13 | — | — | EP | claimed |
| WO-2011064328-A1 | TRIAZOLOPYRIDINE DERIVATIVES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-06-03 | — | — | WO | claimed |
| EP-2507236-B1 | Triazolopyridine derivates | BAYER IP GMBH (DE) | 2014-12-17 | — | — | EP | disclosed |
| EP-2507236-B1 | Triazolopyridine derivates | BAYER IP GMBH (DE) | 2014-12-17 | — | — | EP | disclosed |
| US-20130121994-A1 | TRIAZOLOPYRIDINE DERIVATIVES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-16 | — | — | US | disclosed |
| US-20130121994-A1 | TRIAZOLOPYRIDINE DERIVATIVES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-16 | — | — | US | disclosed |
| EP-2343295-A1 | Triazolopyridine derivates | Bayer Schering Pharma AG (DE) | 2011-07-13 | — | — | EP | disclosed |
| EP-2343295-A1 | Triazolopyridine derivates | Bayer Schering Pharma AG (DE) | 2011-07-13 | — | — | EP | disclosed |
| WO-2011064328-A1 | TRIAZOLOPYRIDINE DERIVATIVES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130121994-A1 | TRIAZOLOPYRIDINE DERIVATIVES | TTBK1, BUB1, TTK | TTK 3/4885LRRK2 1012/4885JAK2 926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.