Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 9/20 | 0.47 |
| ▸ | WDR91 | A4D1P6 | 5/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19331081 | 0.89 | PHGDH (0.50) | PHGDHWDR91PDE2AP2RX7EGFR | |
| SCHEMBL19331026 | 0.87 | PHGDH (0.36) | PHGDHWDR91PDE2AP2RX7 | |
| SCHEMBL19331147 | 0.87 | PHGDH (0.42) | PHGDHWDR91PDE2A | |
| SCHEMBL19330953 | 0.86 | PHGDH (0.41) | PHGDHPDE2AP2RX7EGFRCDK2 | |
| SCHEMBL19331265 | 0.86 | PHGDH (0.35) | PHGDHWDR91PDE2AP2RX7 | |
| SCHEMBL19330944 | 0.84 | PHGDH (0.36) | PHGDHPDE2AP2RX7 | |
| SCHEMBL19331383 | 0.84 | PHGDH (0.44) | PHGDHWDR91 | |
| SCHEMBL19331111 | 0.84 | PHGDH (0.37) | PHGDHPDE2AEGFRCDK2 | |
| SCHEMBL19331329 | 0.82 | PHGDH (0.42) | PHGDHP2RX7EGFRCDK2 | |
| SCHEMBL19330987 | 0.81 | PHGDH (0.35) | PHGDHPDE2AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426243-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | Raze Therapeutics Inc. (US) | 2019-01-16 | — | — | EP | disclosed |
| WO-2017156165-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |