Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1933711 | 0.96 | CHRNA7 (0.42) | PRMT5WDR77CHRNA7ATMNPSR1 | |
| SCHEMBL1791199 | 0.88 | CHRNA7 (0.44) | CHRNA7ATMALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1789276 | 0.85 | ATM (0.48) | CHRNA7ATMALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1786583 | 0.85 | ATM (0.47) | PRMT5WDR77ATMNPSR1ROCK2 | |
| SCHEMBL1786982 | 0.84 | ATM (0.50) | CHRNA7ATMALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1786994 | 0.82 | PRMT5 (0.48) | PRMT5WDR77ATMNPSR1ROCK2 | |
| SCHEMBL1785783 | 0.82 | CHRNA7 (0.41) | CHRNA7ATMALDH1A1PARP1KDM4E | |
| SCHEMBL1790181 | 0.81 | PRMT5 (0.47) | PRMT5WDR77ATMNPSR1ROCK2 | |
| SCHEMBL1789261 | 0.79 | ATM (0.50) | PRMT5ATMNPSR1ROCK2ROCK1 | |
| SCHEMBL19902284 | 0.76 | PRMT5 (0.45) | PRMT5WDR77ATMNPSR1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011066168-A1 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2011-06-03 | — | — | WO | disclosed |