Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19332317 | 0.82 | DAO (0.52) | CYP1A2XDHULK1NR4A2HRH4 | |
| SCHEMBL30310454 | 0.82 | DAO (0.52) | CYP1A2XDHULK1NR4A2HRH4 | |
| SCHEMBL19331400 | 0.81 | HRH4 (0.56) | NPC1RAB9ACYP1A2XDHULK1 | |
| SCHEMBL30039640 | 0.81 | HRH4 (0.56) | NPC1RAB9ACYP1A2XDHULK1 | |
| SCHEMBL24190146 | 0.81 | ABL1 (0.46) | NOTUMCYP1A2XDHULK1NR4A2 | |
| SCHEMBL30396884 | 0.81 | ABL1 (0.46) | NOTUMCYP1A2XDHULK1NR4A2 | |
| SCHEMBL19331227 | 0.80 | CYP1A2 (0.45) | NPC1RAB9ACYP1A2XDHULK1 | |
| SCHEMBL30310487 | 0.79 | GLA (0.47) | CYP1A2XDHULK1MAPTNR4A2 | |
| SCHEMBL19330914 | 0.79 | GLA (0.47) | CYP1A2XDHULK1MAPTNR4A2 | |
| SCHEMBL19332262 | 0.79 | CYP1A2 (0.44) | NPC1RAB9ACYP1A2XDHULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017156181-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |