Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.67 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.67 |
| ▸ | EGFR | P00533 | 14/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.56 |
| ▸ | MLNR | O43193 | 1/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19336993 | 0.90 | MKNK2 (0.66) | MKNK2MKNK1EGFRHDAC1HDAC3 | |
| SCHEMBL19337211 | 0.87 | MKNK1 (0.61) | MKNK2MKNK1EGFRHDAC1HDAC3 | |
| SCHEMBL19336992 | 0.84 | EGFR (0.73) | EGFRMLNRKDM1AABCB11ERBB2 | |
| SCHEMBL29525375 | 0.83 | MKNK2 (0.74) | MKNK2MKNK1EGFRHDAC1HDAC3 | |
| SCHEMBL17822329 | 0.83 | MKNK2 (0.74) | MKNK2MKNK1EGFRHDAC1HDAC3 | |
| SCHEMBL18870128 | 0.82 | MKNK2 (0.75) | MKNK2MKNK1EGFRHDAC1HDAC3 | |
| SCHEMBL19336960 | 0.82 | EGFR (0.75) | EGFRMLNRKDM1AABCB11ERBB2 | |
| SCHEMBL17553562 | 0.81 | MKNK1 (0.63) | MKNK2MKNK1EGFRMLNRKDM1A | |
| SCHEMBL30883801 | 0.81 | MKNK1 (0.63) | MKNK2MKNK1EGFRMLNRKDM1A | |
| SCHEMBL30129335 | 0.81 | MKNK2 (0.79) | MKNK2MKNK1EGFRHDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3216786-A1 | PYRIMIDINE OR PYRIDINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USES THEREOF | Shanghai Shaletech Technology Co., Ltd. (CN) | 2017-09-13 | — | — | EP | disclosed |