Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 5/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17542604 | 0.79 | MKNK2 (0.53) | CDK2DYRK1BGSK3BDYRK1AMKNK2 | |
| SCHEMBL29419125 | 0.77 | MKNK1 (0.50) | CDK2DYRK1AMKNK2MKNK1KDM4E | |
| SCHEMBL5096322 | 0.77 | MKNK1 (0.50) | CDK2DYRK1AMKNK2MKNK1KDM4E | |
| SCHEMBL19532488 | 0.77 | MKNK2 (0.54) | CDK2DYRK1BGSK3BDYRK1AMKNK2 | |
| SCHEMBL19337254 | 0.76 | GSK3B (0.40) | CDK2DYRK1BGSK3BDYRK1AMKNK2 | |
| SCHEMBL19699869 | 0.75 | EGFR (0.51) | EGFR | |
| SCHEMBL30701116 | 0.74 | MKNK2 (0.40) | CDK2DYRK1BGSK3BDYRK1AMKNK2 | |
| SCHEMBL29048360 | 0.74 | MKNK2 (0.40) | CDK2DYRK1BGSK3BDYRK1AMKNK2 | |
| SCHEMBL17542623 | 0.74 | MKNK1 (0.53) | CDK2DYRK1BGSK3BDYRK1AMKNK2 | |
| SCHEMBL30883818 | 0.73 | GSK3B (0.49) | CDK2DYRK1BGSK3BDYRK1AMKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3216786-A1 | PYRIMIDINE OR PYRIDINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USES THEREOF | Shanghai Shaletech Technology Co., Ltd. (CN) | 2017-09-13 | — | — | EP | disclosed |