Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 9/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1786120 | 0.90 | NPSR1 (0.46) | ATMNPSR1LMNAALDH1A1GAA | |
| SCHEMBL1932753 | 0.86 | NPSR1 (0.54) | ROCK1ROCK2ATMNPSR1LMNA | |
| SCHEMBL1931814 | 0.86 | ATM (0.54) | ROCK1ROCK2ATMNPSR1LMNA | |
| SCHEMBL1788381 | 0.86 | ATM (0.67) | ROCK1ROCK2ATMNPSR1LMNA | |
| SCHEMBL1934226 | 0.83 | PDE4A (0.52) | ROCK1ROCK2ATMNPSR1LMNA | |
| SCHEMBL24000703 | 0.78 | ATM (0.63) | ROCK1ROCK2ATMNPSR1LMNA | |
| SCHEMBL24000505 | 0.78 | ATM (0.63) | ROCK1ROCK2ATMNPSR1LMNA | |
| Hydrochloric Acid SCHEMBL30088932 | 0.77 | ATM (0.61) | ROCK1ROCK2ATMNPSR1LMNA | |
| Hydrochloric Acid SCHEMBL30088836 | 0.77 | ATM (0.61) | ROCK1ROCK2ATMNPSR1LMNA | |
| SCHEMBL8864712 | 0.75 | HPGD (0.63) | NPSR1KDM4EALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504317-A1 | POTASSIUM CHANNEL MODULATORS | Abbott Laboratories (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011066168-A1 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2011-06-03 | — | — | WO | disclosed |