Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | DPYD | Q12882 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21864438 | 0.74 | GAA (0.34) | GAAMAPTDPYDALDH1A1LMNA | |
| SCHEMBL21864520 | 0.74 | GAA (0.34) | GAAMAPTDPYDALDH1A1LMNA | |
| SCHEMBL16130127 | 0.69 | GAA (0.37) | GAAMAPTDPYDALDH1A1LMNA | |
| SCHEMBL16629496 | 0.69 | GAA (0.37) | GAAMAPTDPYDALDH1A1LMNA | |
| SCHEMBL21275612 | 0.69 | GAA (0.37) | GAAMAPTDPYDALDH1A1LMNA | |
| SCHEMBL16098132 | 0.69 | GAA (0.37) | GAAMAPTDPYDALDH1A1LMNA | |
| SCHEMBL3561548 | 0.68 | DPYD (0.45) | GAAMAPTDPYDALDH1A1LMNA | |
| SCHEMBL21275630 | 0.68 | SLC5A2 (0.37) | GAAMAPTDPYDALDH1A1LMNA | |
| SCHEMBL15799908 | 0.68 | SLC5A2 (0.37) | GAAMAPTDPYDALDH1A1LMNA | |
| SCHEMBL15800009 | 0.68 | SLC5A2 (0.37) | GAAMAPTDPYDALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3750903-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | Translate Bio, Inc. (US) | 2020-12-16 | — | — | EP | disclosed |
| EP-3301102-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | Translate Bio, Inc. (US) | 2018-04-04 | — | — | EP | disclosed |
| EP-2970351-B1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | TRANSLATE BIO INC (US) | 2017-09-13 | — | — | EP | disclosed |