Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2316135 | 1.00 | EPHX2 (0.43) | EPHX2MAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL4988276 | 1.00 | EPHX2 (0.43) | EPHX2MAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL2842255 | 1.00 | EPHX2 (0.43) | EPHX2MAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL3543452 | 1.00 | EPHX2 (0.43) | EPHX2MAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL16678151 | 0.82 | EPHX2 (0.44) | EPHX2MAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL7080802 | 0.82 | EPHX2 (0.44) | EPHX2MAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL924280 | 0.82 | EPHX2 (0.44) | EPHX2MAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL7158785 | 0.82 | EPHX2 (0.44) | EPHX2MAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL6831561 | 0.82 | EPHX2 (0.44) | EPHX2MAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL6043241 | 0.82 | EPHX2 (0.44) | EPHX2MAPTMAPK1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504324-B1 | SULTAM DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2015-02-25 | — | — | EP | claimed |
| EP-2504324-B1 | SULTAM DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2015-02-25 | — | — | EP | disclosed |
| US-8314250-B2 | Sultam derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-11-20 | — | — | US | disclosed |
| EP-2504324-A1 | SULTAM DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011064141-A1 | SULTAM DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-03 | — | — | WO | disclosed |