Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 8/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.53 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.53 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12129851 | 1.00 | SMO (0.67) | SMOALDH1A1MAPTALOX12LMNA | |
| SCHEMBL8223133 | 0.88 | TSHR (0.54) | SMOALDH1A1LMNATDP1TSHR | |
| SCHEMBL1342152 | 0.84 | MEN1 (0.60) | ALDH1A1MAPTALOX12LMNATDP1 | |
| SCHEMBL19337794 | 0.84 | TSHR (0.49) | SMOALDH1A1LMNATDP1TSHR | |
| SCHEMBL15492188 | 0.82 | KCNK3 (0.49) | SMOALDH1A1TSHRKCNK3KCNK9 | |
| SCHEMBL19326789 | 0.81 | SMO (0.61) | SMOALDH1A1MAPTALOX12LMNA | |
| SCHEMBL1336819 | 0.81 | SMO (0.83) | SMOALDH1A1MAPTALOX12LMNA | |
| SCHEMBL29390703 | 0.81 | SMO (1.00) | SMOALDH1A1MAPTALOX12LMNA | |
| SCHEMBL12129860 | 0.81 | SMO (1.00) | SMOALDH1A1MAPTALOX12LMNA | |
| SCHEMBL19326792 | 0.80 | SMO (0.85) | SMOALDH1A1MAPTALOX12LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291352-B1 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | CENTRE NAT RECH SCIENT (FR) | 2017-09-13 | — | — | EP | disclosed |