Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 20/20 | 0.82 |
| ▸ | FGFR2 | P21802 | 15/20 | 0.82 |
| ▸ | FGFR4 | P22455 | 15/20 | 0.82 |
| ▸ | FGFR3 | P22607 | 15/20 | 0.82 |
| ▸ | KDR | P35968 | 10/20 | 0.82 |
| ▸ | FLT1 | P17948 | 9/20 | 0.82 |
| ▸ | FLT4 | P35916 | 9/20 | 0.82 |
| ▸ | SRC | P12931 | 4/20 | 0.82 |
| ▸ | GLA | P06280 | 1/20 | 0.82 |
| ▸ | CSK | P41240 | 1/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.82 |
| ▸ | ATM | Q13315 | 1/20 | 0.82 |
| ▸ | EGFR | P00533 | 4/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.57 |
| ▸ | PRKCG | P05129 | 1/20 | 0.57 |
| ▸ | PRKCB | P05771 | 1/20 | 0.57 |
| ▸ | PRKCA | P17252 | 1/20 | 0.57 |
| ▸ | PRKCH | P24723 | 1/20 | 0.57 |
| ▸ | PRKCI | P41743 | 1/20 | 0.57 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19338070 | 0.95 | FGFR1 (0.75) | FGFR1FGFR2FGFR4FGFR3KDR | |
| Pd-173074 SCHEMBL29828472 | 0.90 | FGFR1 (1.00) | FGFR1FGFR2FGFR4FGFR3KDR | |
| Pd-173074 SCHEMBL177946 | 0.90 | FGFR1 (1.00) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL19338054 | 0.89 | FGFR1 (0.65) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL22144559 | 0.88 | FGFR1 (0.95) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL16489372 | 0.86 | FGFR1 (0.91) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL17814860 | 0.85 | FGFR1 (0.90) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL22130753 | 0.85 | FGFR1 (0.74) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL15624527 | 0.84 | FGFR1 (0.87) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL30738006 | 0.84 | FGFR1 (1.00) | FGFR1FGFR2FGFR4FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2902489-B9 | FGFR3 FUSION GENE AND PHARMACEUTICAL DRUG TARGETING SAME | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-02-07 | — | — | EP | disclosed |
| EP-2902489-B1 | FGFR3 FUSION GENE AND PHARMACEUTICAL DRUG TARGETING SAME | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-09-13 | — | — | EP | disclosed |