Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 2/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 13/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 13/20 | 0.40 |
| ▸ | PRCP | P42785 | 2/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2710075 | 0.94 | NR1I2 (0.45) | NR1I2HCRTR1HCRTR2PRCPCHEK2 | |
| SCHEMBL205289 | 0.94 | NR1I2 (0.45) | NR1I2HCRTR1HCRTR2PRCPCHEK2 | |
| SCHEMBL12075270 | 0.91 | SCN10A (0.44) | NR1I2SCN10AHCRTR1HCRTR2PRCP | |
| SCHEMBL10201491 | 0.91 | SCN10A (0.46) | NR1I2SCN10AHCRTR1HCRTR2PRCP | |
| SCHEMBL27978678 | 0.91 | PRCP (0.44) | NR1I2HCRTR1HCRTR2PRCPCHEK2 | |
| SCHEMBL8749325 | 0.90 | HCRTR1 (0.44) | NR1I2SCN10AHCRTR1HCRTR2PRCP | |
| SCHEMBL19339621 | 0.87 | SCN10A (0.52) | SCN10AHCRTR1HCRTR2CHEK2 | |
| SCHEMBL18462513 | 0.86 | PRCP (0.50) | NR1I2HCRTR1HCRTR2PRCPABCB11 | |
| SCHEMBL2709583 | 0.86 | PRCP (0.50) | NR1I2HCRTR1HCRTR2PRCPABCB11 | |
| SCHEMBL204446 | 0.86 | PRCP (0.50) | NR1I2HCRTR1HCRTR2PRCPABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3309157-A1 | ANTIVIRAL COMPOUNDS | Gilead Pharmasset LLC (US) | 2018-04-18 | — | — | EP | disclosed |
| EP-3002281-B1 | ANTIVIRAL COMPOUNDS | GILEAD PHARMASSET LLC (US) | 2017-09-13 | — | — | EP | disclosed |