Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7405713 | 0.79 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2L3MBTL1CYP2C19 | |
| Hydrochloric Acid SCHEMBL4039829 | 0.77 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2L3MBTL1CYP2C19 | |
| Hydrochloric Acid SCHEMBL8512475 | 0.76 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2L3MBTL1CYP2C19 | |
| SCHEMBL4866049 | 0.75 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2L3MBTL1CYP2C19 | |
| SCHEMBL28150248 | 0.75 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2L3MBTL1CYP2C19 | |
| SCHEMBL7406324 | 0.72 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2L3MBTL1CYP2C19 | |
| SCHEMBL2302032 | 0.72 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2L3MBTL1CYP2C19 | |
| SCHEMBL6620544 | 0.71 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2L3MBTL1CYP2C19 | |
| SCHEMBL6624131 | 0.71 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2L3MBTL1CYP2C19 | |
| SCHEMBL28572864 | 0.71 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2L3MBTL1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011068926-A1 | IAP INHIBITORS | TETRALOGIC PHARMACEUTICALS CORP. (US) | 2011-06-09 | — | — | WO | disclosed |