Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | KYAT1 | Q16773 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4395363 | 1.00 | MEN1 (0.44) | MEN1KMT2AABCB1KYAT1MAPT | |
| SCHEMBL22621727 | 0.90 | TSHR (0.50) | MEN1KMT2AABCB1KYAT1MAPT | |
| SCHEMBL19341959 | 0.90 | TSHR (0.50) | MEN1KMT2AABCB1KYAT1MAPT | |
| SCHEMBL4408498 | 0.90 | TSHR (0.50) | MEN1KMT2AABCB1KYAT1MAPT | |
| SCHEMBL6141984 | 0.88 | POLB (0.54) | MEN1KMT2AABCB1KYAT1MAPT | |
| SCHEMBL16855424 | 0.88 | POLB (0.54) | MEN1KMT2AABCB1KYAT1MAPT | |
| SCHEMBL6141981 | 0.88 | POLB (0.54) | MEN1KMT2AABCB1KYAT1MAPT | |
| SCHEMBL22760545 | 0.88 | HPGD (0.48) | MEN1KMT2AABCB1KYAT1MAPT | |
| SCHEMBL4406573 | 0.88 | HPGD (0.48) | MEN1KMT2AABCB1KYAT1MAPT | |
| SCHEMBL23367356 | 0.84 | MEN1 (0.42) | MEN1KMT2AABCB1KYAT1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017156177-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |
| WO-2017156181-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |