Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19343899 | 0.91 | PRMT5 (0.41) | PRMT5WDR77 | |
| SCHEMBL19343845 | 0.79 | PRMT5 (0.49) | PRMT5WDR77 | |
| SCHEMBL19343887 | 0.77 | PIK3R1 (0.35) | PRMT5WDR77 | |
| SCHEMBL19344128 | 0.76 | PRMT5 (0.55) | PRMT5WDR77 | |
| SCHEMBL19343829 | 0.73 | PRMT5 (0.50) | PRMT5WDR77 | |
| SCHEMBL19343880 | 0.73 | PRMT5 (0.58) | PRMT5WDR77 | |
| SCHEMBL19343825 | 0.72 | PRMT5 (0.61) | PRMT5WDR77 | |
| SCHEMBL19343823 | 0.71 | PRMT5 (0.48) | PRMT5WDR77 | |
| SCHEMBL19343817 | 0.71 | PRMT5 (0.57) | PRMT5WDR77 | |
| SCHEMBL19344424 | 0.67 | PRMT5 (0.39) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |
| WO-2017153186-A1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-14 | — | — | WO | disclosed |