Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 13/20 | 0.61 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19344011 | 0.81 | PRMT5 (0.75) | PRMT5WDR77SMN1; SMN2 | |
| SCHEMBL19344128 | 0.80 | PRMT5 (0.55) | PRMT5WDR77 | |
| SCHEMBL19344171 | 0.75 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL19344073 | 0.73 | PRMT5 (0.81) | PRMT5WDR77SMN1; SMN2 | |
| SCHEMBL19344117 | 0.72 | PRMT5 (0.78) | PRMT5WDR77 | |
| SCHEMBL19344023 | 0.71 | PRMT5 (0.77) | PRMT5WDR77 | |
| SCHEMBL19344315 | 0.71 | PRMT5 (0.71) | PRMT5WDR77 | |
| SCHEMBL19344622 | 0.71 | PRMT5 (0.71) | PRMT5WDR77 | |
| SCHEMBL19344319 | 0.71 | PRMT5 (0.71) | PRMT5WDR77 | |
| SCHEMBL19344030 | 0.70 | PRMT5 (0.75) | PRMT5WDR77SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017153186-A1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-14 | — | — | WO | disclosed |