Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 10/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.46 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.35 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19344047 | 0.95 | PRMT5 (0.48) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL19344405 | 0.94 | PRMT5 (0.49) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL19344252 | 0.92 | PRMT5 (0.47) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL19344270 | 0.92 | PRMT5 (0.54) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL19344250 | 0.91 | PRMT5 (0.44) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL22434985 | 0.89 | PRMT5 (0.39) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL19344045 | 0.88 | PRMT5 (0.36) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL19344035 | 0.87 | PRMT5 (0.39) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL19344126 | 0.87 | PRMT5 (0.57) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL19343848 | 0.87 | EIF2AK4 (0.37) | PRMT5WDR77PI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |
| WO-2017153186-A1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-14 | — | — | WO | disclosed |