Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 16/20 | 0.73 |
| ▸ | WDR77 | Q9BQA1 | 12/20 | 0.73 |
| ▸ | ADK | P55263 | 1/20 | 0.44 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.41 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19344166 | 0.94 | PRMT5 (0.78) | PRMT5WDR77ADKDNMT1DNMT3B | |
| SCHEMBL19344300 | 0.94 | PRMT5 (0.78) | PRMT5WDR77ADKDNMT1DNMT3B | |
| SCHEMBL19344131 | 0.92 | PRMT5 (0.70) | PRMT5WDR77ADKDNMT1DNMT3B | |
| SCHEMBL19343915 | 0.89 | PRMT5 (0.57) | PRMT5WDR77ADK | |
| SCHEMBL19344134 | 0.86 | PRMT5 (0.75) | PRMT5WDR77ADKDNMT1DNMT3B | |
| SCHEMBL19344595 | 0.86 | PRMT5 (0.75) | PRMT5WDR77ADKDNMT1DNMT3B | |
| SCHEMBL19344171 | 0.84 | PRMT5 (1.00) | PRMT5WDR77ADKDNMT1DNMT3B | |
| SCHEMBL19344146 | 0.83 | PRMT5 (0.69) | PRMT5WDR77ADKDNMT1DNMT3B | |
| SCHEMBL19343929 | 0.81 | PRMT5 (0.56) | PRMT5WDR77ADKDNMT1DNMT3B | |
| SCHEMBL19344231 | 0.81 | PRMT5 (0.59) | PRMT5WDR77ADKDNMT1DNMT3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |
| WO-2017153186-A1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-14 | — | — | WO | disclosed |