Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 4/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | PI4K2A | Q9BTU6 | 5/20 | 0.46 |
| ▸ | PI4KA | P42356 | 4/20 | 0.46 |
| ▸ | PI4K2B | Q8TCG2 | 4/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.46 |
| ▸ | ADA | P00813 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584782 | 0.95 | PRMT5 (0.54) | PRMT5WDR77BCHEPI4K2API4KA | |
| SCHEMBL23584632 | 0.95 | PRMT5 (0.48) | PRMT5WDR77BCHEPI4K2API4KA | |
| SCHEMBL23584573 | 0.94 | PRMT5 (0.51) | PRMT5WDR77BCHEPI4K2API4KA | |
| SCHEMBL23584824 | 0.91 | PRMT5 (0.52) | PRMT5WDR77BCHEPI4K2API4KA | |
| SCHEMBL23584750 | 0.90 | PRMT5 (0.50) | PRMT5WDR77BCHEPI4K2API4KA | |
| SCHEMBL23584804 | 0.88 | PRMT5 (0.54) | PRMT5WDR77BCHEPI4K2API4KA | |
| SCHEMBL23584728 | 0.86 | BCHE (0.46) | PRMT5WDR77BCHEPI4K2API4KA | |
| SCHEMBL22434821 | 0.85 | PRMT5 (0.60) | PRMT5WDR77BCHEPI4K2API4KA | |
| SCHEMBL23584775 | 0.85 | PRMT5 (0.53) | PRMT5WDR77BCHEPI4K2API4KA | |
| SCHEMBL23584501 | 0.85 | PI4KA (0.49) | PRMT5WDR77BCHEPI4K2API4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |
| WO-2017153186-A1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-14 | — | — | WO | disclosed |