Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2833020 | 0.80 | MEN1 (0.36) | NPSR1NPC1RAB9ACA12CA9 | |
| SCHEMBL1933707 | 0.79 | NPSR1 (0.38) | NPSR1NPC1RAB9ACA12CA9 | |
| SCHEMBL1509096 | 0.79 | NPC1 (0.40) | NPSR1NPC1RAB9ACA12CA9 | |
| SCHEMBL17085678 | 0.78 | CNR2 (0.41) | NPSR1NPC1RAB9ACA12CA9 | |
| SCHEMBL2830142 | 0.75 | NPSR1 (0.38) | NPSR1NPC1RAB9ACA12CA9 | |
| SCHEMBL2836772 | 0.74 | NPSR1 (0.39) | NPSR1NPC1RAB9ACA12CA9 | |
| SCHEMBL1509098 | 0.70 | NPC1 (0.41) | NPSR1NPC1RAB9ACA12CA9 | |
| SCHEMBL19580264 | 0.69 | CNR2 (0.52) | NPSR1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL18190832 | 0.68 | CNR2 (0.45) | NPSR1NPC1RAB9ACA12CA9 | |
| SCHEMBL23582907 | 0.68 | DDB1 (0.48) | KMT2ATDP1LMNAALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2506716-A1 | NOVEL TRICYCLIC COMPOUNDS | Abbott Laboratories (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011068881-A1 | NOVEL TRICYCLIC COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |