Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 10/20 | 0.55 |
| ▸ | CDK8 | P49336 | 10/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | GSK3A | P49840 | 1/20 | 0.55 |
| ▸ | CDK9 | P50750 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.51 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.49 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.46 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17514255 | 1.00 | CCNC (0.55) | CCNCCDK8DRD2GSK3ACDK9 | |
| SCHEMBL17514179 | 1.00 | CCNC (0.55) | CCNCCDK8DRD2GSK3ACDK9 | |
| SCHEMBL17514178 | 0.97 | CCNC (0.59) | CCNCCDK8DRD2GSK3ACDK9 | |
| SCHEMBL17514180 | 0.97 | CCNC (0.59) | CCNCCDK8DRD2GSK3ACDK9 | |
| SCHEMBL19349773 | 0.97 | CCNC (0.59) | CCNCCDK8DRD2GSK3ACDK9 | |
| SCHEMBL19349724 | 0.90 | CCNC (0.60) | CCNCCDK8DRD2GSK3ACDK9 | |
| SCHEMBL17514194 | 0.90 | CCNC (0.60) | CCNCCDK8DRD2GSK3ACDK9 | |
| SCHEMBL17514254 | 0.90 | CCNC (0.60) | CCNCCDK8DRD2GSK3ACDK9 | |
| SCHEMBL19349646 | 0.89 | CCNC (0.68) | CCNCCDK8DRD2GSK3ACDK9 | |
| SCHEMBL19368000 | 0.89 | CCNC (0.58) | CCNCCDK8DRD2GSK3ACDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3183239-B1 | INDAZOLES | MERCK PATENT GMBH (DE) | 2018-09-26 | — | — | EP | disclosed |
| US-9862717-B2 | Indazoles | MERCK PATENT GMBH (DE) | 2018-01-09 | — | — | US | disclosed |
| US-9862717-B2 | Indazoles | MERCK PATENT GMBH (DE) | 2018-01-09 | — | — | US | disclosed |
| US-20170267675-A1 | INDAZOLES | MERCK PATENT GMBH (DE) | 2017-09-21 | — | — | US | disclosed |
| US-20170267675-A1 | INDAZOLES | MERCK PATENT GMBH (DE) | 2017-09-21 | — | — | US | disclosed |
| US-20170267675-A1 | INDAZOLES | MERCK PATENT GMBH (DE) | 2017-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267675-A1 | INDAZOLES | MKI67, CCNI, BRCA1 | CCNC 94/4885CDK8 242/4885DRD2 4481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.