Indole-2-Carboxylic Acid

Indole-2-Carboxylic Acid

SCHEMBL1935

O=C(O)c1cc2ccccc2[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 1.00
HSD17B10 Q99714 5/20 1.00
HPGD P15428 4/20 1.00
MAPT P10636 1/20 1.00
DAO P14920 1/20 1.00
SRD5A2 P31213 1/20 1.00
FLT3 P36888 4/20 0.74
LMNA P02545 3/20 0.64
IDO1 P14902 1/20 0.64
NPC1 O15118 1/20 0.64
RAB9A P51151 1/20 0.64
SMN1; SMN2 Q16637 1/20 0.64
ALDH1A1 P00352 5/20 0.62
GAA P10253 2/20 0.62
MAPK1 P28482 2/20 0.62
SMAD3 P84022 1/20 0.61
KMT2A Q03164 3/20 0.60
CYP2C19 P33261 2/20 0.59
MEN1 O00255 2/20 0.59
F7 P08709 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Indole-2-Carboxylic Acid SCHEMBL29395165 1.00 KDM4E (1.00) KDM4EHSD17B10HPGDMAPTDAO
Indole-2-Carboxylic Acid SCHEMBL31620677 0.98 KDM4E (0.96) KDM4EHSD17B10HPGDMAPTDAO
Indole-2-Carboxylic Acid SCHEMBL3297085 0.98 KDM4E (0.96) KDM4EHSD17B10HPGDMAPTDAO
Indole-2-Carboxylic Acid SCHEMBL28209082 0.98 KDM4E (0.96) KDM4EHSD17B10HPGDMAPTDAO
Indole-2-Carboxylic Acid SCHEMBL5243678 0.98 KDM4E (0.96) KDM4EHSD17B10HPGDMAPTDAO
Indole-2-Carboxylic Acid SCHEMBL9514556 0.98 KDM4E (0.96) KDM4EHSD17B10HPGDMAPTDAO
Indole-2-Carboxylic Acid SCHEMBL5243668 0.98 KDM4E (0.96) KDM4EHSD17B10HPGDMAPTDAO
Indole-2-Carboxylic Acid SCHEMBL11743045 0.98 KDM4E (0.96) KDM4EHSD17B10HPGDMAPTDAO
Indole-2-Carboxylic Acid SCHEMBL28178562 0.98 KDM4E (0.96) KDM4EHSD17B10HPGDMAPTDAO
Indole-2-Carboxylic Acid SCHEMBL27530753 0.98 KDM4E (0.96) KDM4EHSD17B10HPGDMAPTDAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8971 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122036585-A Synthesis method of indole carboxylic acid compound 北京化工大学 2026-05-15 CN claimed
US-20260070905-A1 Derivatives of Imidazo[1,2-A]Pyridine with Anti-Inflammatory Activity UNIV DE VELENCIA (ES) 2026-03-12 US claimed
US-12570632-B2 Indole derivatives and uses thereof for treating a cancer UNIVERSITE CLAUDE BERNARD LYON 1 (FR) 2026-03-10 US claimed
CN-121574172-A Hederagenin C-23 heterocyclic ester derivative, and preparation method and application thereof 烟台大学 2026-02-27 CN claimed
EP-4646404-A1 PEPTIDE-HISTIDINAL CONJUGATES AS AN ANTI-MALARIAL AGENTS Council of Scientific & Industrial Research (IN) 2025-11-12 EP claimed
EP-4607278-A1 CHEMICALLY-AMPLIFIED POSITIVE PHOTORESIST COMPOSITION FOR PATTERN PROFILE IMPROVEMENT AND ETCH RESISTANCE ENHANCEMENT Ycchem Co., Ltd. (KR) 2025-08-27 EP claimed
US-20250199405-A1 CHEMICALLY-AMPLIFIED POSITIVE PHOTORESIST COMPOSITION FOR PATTERN PROFILE IMPROVEMENT AND ETCH RESISTANCE ENHANCEMENT YCCHEM CO., LTD. (KR) 2025-06-19 US claimed
CN-113929663-B AZD 9291-2-indole formate and preparation method thereof 鲁南制药集团股份有限公司 2025-06-17 CN claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
CN-119998727-A Chemically amplified positive resist composition for improving pattern profile and enhancing etch resistance YC化学制品株式会社 2025-05-13 CN claimed
EP-0088252-B1 PROCESS FOR THE PREPARATION OF 1-(4-CHLORBENZOYL)-5-METHOXY-2-METHYL-3-INDOLACETOXY-ACETIC ACID Troponwerke GmbH & Co. KG (DE) 1986-04-09 EP claimed
US-4535168-A Preparation of indoline-2-carboxylic acid via the intermediate indoline-2-carboxylic acid ester tin complex AMERICAN HOME PRODUCTS CORPORATION (US) 1985-08-13 US claimed
US-4496651-A RUPTURABLE CONTAINER FOR DIFFUSION TRANSFER POLAROID CORPORATION (US) 1985-01-29 US claimed
US-4485241-A Reduction of indole-2-carboxylic acids to indoline-2-carboxylic acids with lithium, sodium, or potassium in ammonia AMERICAN HOME PRODUCTS CORPORATION (US) 1984-11-27 US claimed
US-4477677-A Process for the preparation of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetoxyacetic acid TROPONWERKE GMBH & CO. KG (DE) 1984-10-16 US claimed
US-4459415-A Process for the preparation of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetoxyacetic acid TROPONWERKE GMBH & CO. KG (DE) 1984-07-10 US claimed
US-4456674-A IIA HALIDES TO INCREASE ABSORTION OF PHTHALEIN OPTICAL FILTER POLAROID CORPORATION (US) 1984-06-26 US claimed
EP-0110578-A2 Colour transfer photographic processes and products POLAROID CORPORATION (US) 1984-06-13 EP claimed
EP-0043752-B1 PYRANOINDOLE DERIVATIVE AND PROCESS FOR ITS PREPARATION SOCIETE DE RECHERCHES INDUSTRIELLES S.O.R.I. Société anonyme dite: (FR) 1984-06-13 EP claimed
EP-0092380-A2 Antiallergic 4H-furo(3,2-b)indoles and their production WARNER-LAMBERT COMPANY (US) 1983-10-26 EP claimed