Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 6/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 4/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20892953 | 1.00 | EPHX1 (0.40) | EPHX1SMYD3TEAD1POLBTSHR | |
| SCHEMBL19353525 | 1.00 | EPHX1 (0.40) | EPHX1SMYD3TEAD1POLBTSHR | |
| SCHEMBL20892801 | 1.00 | EPHX1 (0.40) | EPHX1SMYD3TEAD1POLBTSHR | |
| SCHEMBL20892805 | 1.00 | EPHX1 (0.40) | EPHX1SMYD3TEAD1POLBTSHR | |
| SCHEMBL19353270 | 1.00 | EPHX1 (0.40) | EPHX1SMYD3TEAD1POLBTSHR | |
| SCHEMBL24244484 | 1.00 | EPHX1 (0.40) | EPHX1SMYD3TEAD1POLBTSHR | |
| SCHEMBL19353379 | 0.89 | EPHX1 (0.38) | EPHX1SMYD3TEAD1TSHRALDH1A1 | |
| SCHEMBL19353233 | 0.89 | EPHX1 (0.38) | EPHX1SMYD3TEAD1TSHRALDH1A1 | |
| SCHEMBL16907748 | 0.89 | EPHX1 (0.38) | EPHX1SMYD3TEAD1TSHRALDH1A1 | |
| SCHEMBL19353373 | 0.89 | EPHX1 (0.38) | EPHX1SMYD3TEAD1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017156495-A1 | COMPOUNDS AND METHODS FOR MODULATING BRUTON'S TYROSINE KINASE | CORVUS PHARMACEUTICALS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |