Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19352846 | 0.84 | KMT2A (0.38) | KMT2AMAPTMEN1SMN1; SMN2LMNA | |
| SCHEMBL19352847 | 0.79 | KMT2A (0.37) | KMT2AMAPTMEN1SMN1; SMN2LMNA | |
| SCHEMBL19352848 | 0.79 | KMT2A (0.38) | KMT2AMAPTLMNACYP1A2TSHR | |
| SCHEMBL19329798 | 0.77 | KMT2A (0.36) | KMT2AMAPTMEN1SMN1; SMN2LMNA | |
| SCHEMBL19330067 | 0.77 | KMT2A (0.37) | KMT2AMAPTLMNAL3MBTL1CYP1A2 | |
| SCHEMBL5448926 | 0.73 | FLT3 (0.47) | KMT2AMAPTMEN1SMN1; SMN2NPC1 | |
| SCHEMBL5466938 | 0.72 | CA12 (0.44) | KMT2AMAPTMEN1LMNAGAA | |
| SCHEMBL19329986 | 0.71 | KMT2A (0.36) | KMT2AMAPTLMNACYP1A2POLB | |
| SCHEMBL5451260 | 0.70 | EPHX2 (0.51) | KMT2AMAPTMEN1GAAALDH1A1 | |
| SCHEMBL5453506 | 0.68 | MAPT (0.45) | KMT2AMAPTMEN1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017153789-A1 | BENZO[B]THIOPHENE DERIVATIVES AND THEIR USE FOR THE INHIBITION OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES (FGFRS) FOR THE USE OF NEO- AND HYPERPLASIA THERAPIES | VICHEM CHEMIE KUTATÓ KFT. (HU) | 2017-09-14 | — | — | WO | disclosed |