Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.33 |
| ▸ | TP53 | P04637 | 4/20 | 0.33 |
| ▸ | MME | P08473 | 3/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | FASN | P49327 | 1/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16942396 | 0.91 | PAK1 (0.34) | FFAR4MDM2TP53MMEACE | |
| SCHEMBL19086062 | 0.90 | MME (0.33) | FFAR4MDM2TP53MMEACE | |
| SCHEMBL19376942 | 0.87 | FFAR4 (0.35) | FFAR4MDM2TP53MMEACE | |
| SCHEMBL19331594 | 0.87 | FFAR4 (0.35) | FFAR4MDM2TP53MMEACE | |
| SCHEMBL19355012 | 0.84 | MDM2 (0.32) | FFAR4MDM2TP53MMEACE | |
| SCHEMBL19376972 | 0.84 | MDM2 (0.32) | FFAR4MDM2TP53MMEACE | |
| SCHEMBL29813546 | 0.84 | MDM2 (0.32) | FFAR4MDM2TP53MMEACE | |
| SCHEMBL20597918 | 0.84 | MDM2 (0.32) | FFAR4MDM2TP53MMEACE | |
| SCHEMBL16942417 | 0.84 | PAK1 (0.35) | FFAR4MDM2TP53MMEACE | |
| SCHEMBL19376969 | 0.84 | PAK1 (0.35) | FFAR4MDM2TP53MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3408260-B1 | CRYSTALLINE (2S,4R)-5-(5'-CHLORO-2-FLUORO-[1,1'-BIPHENYL]-4-YL)-2-(ETHOXYMETHYL)-4-(3-HYDROXYISOXAZOLE-5-CARBOXAMIDO)-2-METHYLPENTANOIC ACID AND USES THEREOF | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2021-05-05 | — | — | EP | disclosed |
| WO-2017156009-A1 | CRYSTALLINE(2S,4R)-5-(5'-CHLORO-2'-FLUORO-[1,1'-BIPHENYL]-4-YL)-2-(ETHOXYMETHYL)-4-(3-HYDROXYISOXAZOLE-5-CARBOXAMIDO)-2-METHYLPENTANOIC ACID AND USES THEREOF | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-09-14 | — | — | WO | disclosed |