Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11304999 | 0.97 | HTT (0.60) | HTTGFERSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL10154817 | 0.89 | MAPT (0.63) | HTTGFERSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL15651281 | 0.88 | HTT (0.79) | HTTGFERSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL17572090 | 0.84 | HTT (0.61) | HTTGFERSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL19423896 | 0.83 | HTT (0.60) | HTTGFERSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL10666927 | 0.82 | ECE2 (0.54) | HTTSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL17572088 | 0.82 | HTT (0.61) | HTTGFERSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL23095882 | 0.81 | HTT (0.57) | HTTGFERSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL19419479 | 0.81 | HTT (0.57) | HTTGFERSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL19423882 | 0.81 | HTT (0.60) | HTTGFERSMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189041-B1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | CTXT PTY LTD (AU) | 2021-04-28 | — | — | EP | disclosed |
| EP-3189048-B1 | AMINOINDANE-, AMINOTETRAHYDRONAPHTHALENE- AND AMINOBENZOCYCLOBUTANE-DERIVED PRMT5-INHIBITORS | CTXT PTY LTD (AU) | 2021-03-17 | — | — | EP | disclosed |
| EP-3189042-B1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | CTXT PTY LTD (AU) | 2021-03-17 | — | — | EP | disclosed |
| WO-2017153513-A1 | TETRAHYDROISOQUINOLINES AS PRMT5 INHIBITORS | CTXT PTY LIMITED (AU) | 2017-09-14 | — | — | WO | disclosed |