Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BUB1 | O43683 | 20/20 | 0.72 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.52 |
| ▸ | STK10 | O94804 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.52 |
| ▸ | CDC42BPG | Q6DT37 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19357181 | 0.98 | BUB1 (0.72) | BUB1SLC28A1STK10HTR1ADDR1 | |
| SCHEMBL19357272 | 0.98 | BUB1 (0.71) | BUB1SLC28A1STK10HTR1ADDR1 | |
| SCHEMBL19357220 | 0.98 | BUB1 (0.71) | BUB1SLC28A1STK10HTR1ADDR1 | |
| SCHEMBL19357139 | 0.97 | BUB1 (0.74) | BUB1SLC28A1STK10HTR1ADDR1 | |
| SCHEMBL19357303 | 0.92 | BUB1 (0.71) | BUB1SLC28A1STK10HTR1ADDR1 | |
| SCHEMBL19357270 | 0.91 | BUB1 (0.69) | BUB1 | |
| SCHEMBL19357234 | 0.89 | BUB1 (0.71) | BUB1SLC28A1STK10HTR1ADDR1 | |
| SCHEMBL19357271 | 0.87 | BUB1 (0.66) | BUB1SLC28A1STK10HTR1ADDR1 | |
| SCHEMBL19357213 | 0.86 | BUB1 (0.58) | BUB1SLC28A1STK10HTR1ADDR1 | |
| SCHEMBL19357222 | 0.86 | BUB1 (0.61) | BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017157991-A1 | 1-ALKYL-PYRAZOLES AND -INDAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-21 | — | — | WO | claimed |
| WO-2017157991-A1 | 1-ALKYL-PYRAZOLES AND -INDAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-21 | — | — | WO | disclosed |
| WO-2017157991-A1 | 1-ALKYL-PYRAZOLES AND -INDAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-21 | — | — | WO | disclosed |