Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | KDM4A | O75164 | 2/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM6A | O15550 | 1/20 | 0.41 |
| ▸ | TET3 | O43151 | 1/20 | 0.41 |
| ▸ | KDM4B | O94953 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.41 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19358749 | 1.00 | KDM4E (0.52) | KDM4EKMT2ATP53TDP1MEN1 | |
| SCHEMBL14925180 | 0.87 | KDM4E (0.46) | KDM4EKMT2ATP53TDP1MEN1 | |
| SCHEMBL19358745 | 0.76 | KDM4E (0.62) | KDM4EKMT2ATP53TDP1MEN1 | |
| SCHEMBL2143785 | 0.74 | KDM4E (0.78) | KDM4EKMT2ATP53TDP1MEN1 | |
| SCHEMBL13858129 | 0.73 | KDM4E (0.62) | KDM4EKMT2ATP53TDP1MEN1 | |
| SCHEMBL13255537 | 0.73 | KDM4E (0.58) | KDM4EKMT2ATP53TDP1MEN1 | |
| SCHEMBL1126280 | 0.72 | KMT2A (0.62) | KDM4EKMT2ATP53TDP1MEN1 | |
| SCHEMBL22367842 | 0.71 | KDM4E (0.62) | KDM4EKMT2ATP53TDP1MEN1 | |
| SCHEMBL13943233 | 0.68 | KDM4E (0.51) | KDM4EKMT2ATP53TDP1MEN1 | |
| SCHEMBL6962756 | 0.67 | KDM4E (0.68) | KDM4EKMT2ATP53TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017160670-A1 | M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS AND METHODS OF USE THEREOF | MERCK SHARP & DOHME CORP. (US) | 2017-09-21 | — | — | WO | disclosed |