Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 4/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.32 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2238254 | 0.93 | EP300 (0.39) | EP300HIF1AMCHR1BDKRB1CHRM2 | |
| SCHEMBL2243708 | 0.89 | MCHR1 (0.37) | EP300HIF1AMCHR1BDKRB1CHRM2 | |
| SCHEMBL2237371 | 0.87 | EP300 (0.41) | EP300HIF1ANPC1RAB9AMCHR1 | |
| SCHEMBL2234890 | 0.87 | BDKRB1 (0.42) | MCHR1BDKRB1CHRM2CHRM3MEN1 | |
| SCHEMBL2235503 | 0.86 | EP300 (0.38) | EP300HIF1AMCHR1BDKRB1CHRM2 | |
| SCHEMBL2240269 | 0.86 | BDKRB1 (0.37) | EP300HIF1AMCHR1BDKRB1AVPR1B | |
| SCHEMBL2238443 | 0.85 | EP300 (0.37) | EP300HIF1ANPC1RAB9AMCHR1 | |
| SCHEMBL2235494 | 0.84 | EP300 (0.38) | EP300HIF1AMCHR1BDKRB1CHRM2 | |
| SCHEMBL2238151 | 0.84 | BDKRB1 (0.36) | EP300HIF1AMCHR1BDKRB1AVPR1B | |
| SCHEMBL2236456 | 0.83 | BDKRB1 (0.36) | EP300HIF1AMCHR1BDKRB1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331518-A1 | NEW BRADYKININ B1 ANTAGONISTS | Evotec AG (DE) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010020556-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-02-25 | — | — | WO | disclosed |