Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19381378 | 0.82 | EPHX2 (0.60) | EPHX2CYP2C9CYP2C19LMNAHPGD | |
| SCHEMBL19359257 | 0.82 | EPHX2 (0.60) | EPHX2CYP2C9CYP2C19LMNAHPGD | |
| SCHEMBL5948102 | 0.78 | EPHX2 (1.00) | EPHX2CYP2C9CYP2C19HPGDTPSAB1 | |
| SCHEMBL5947676 | 0.76 | EPHX2 (0.67) | EPHX2CYP2C9CYP2C19LMNAHPGD | |
| SCHEMBL5948064 | 0.74 | EPHX2 (1.00) | EPHX2CYP2C9CYP2C19LMNAHPGD | |
| SCHEMBL5947857 | 0.74 | EPHX2 (0.63) | EPHX2CYP2C9CYP2C19LMNAHPGD | |
| SCHEMBL19359259 | 0.74 | EPHX2 (0.73) | EPHX2CYP2C9CYP2C19LMNAHPGD | |
| SCHEMBL4638764 | 0.73 | EPHX2 (0.87) | EPHX2CYP2C9CYP2C19LMNAHPGD | |
| SCHEMBL5947971 | 0.72 | EPHX2 (0.68) | EPHX2CYP2C9CYP2C19LMNAHPGD | |
| SCHEMBL5213128 | 0.72 | EPHX2 (0.71) | EPHX2CYP2C9CYP2C19LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017161145-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE AND/OR EPX | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-21 | — | — | WO | disclosed |