Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.39 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 8/20 | 0.38 |
| ▸ | SRC | P12931 | 4/20 | 0.37 |
| ▸ | SYK | P43405 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1934788 | 0.93 | BRAF (0.42) | BRAFMAPK14GSK3ASRCSYK | |
| SCHEMBL2671763 | 0.92 | BRAF (0.43) | BRAFMAPK14MAP3K20GSK3ASRC | |
| SCHEMBL1936778 | 0.91 | BRAF (0.41) | BRAFMAPK14MAP3K20GSK3ASRC | |
| SCHEMBL1934596 | 0.91 | BRAF (0.41) | BRAFMAPK14GSK3ASRCSYK | |
| SCHEMBL1935974 | 0.90 | SRC (0.45) | BRAFMAPK14GSK3ASRCSYK | |
| SCHEMBL1935947 | 0.90 | BRAF (0.41) | BRAFMAPK14GSK3ASRCSYK | |
| SCHEMBL1934798 | 0.90 | BRAF (0.45) | BRAFMAPK14GSK3ASRCSYK | |
| SCHEMBL1936218 | 0.90 | BRAF (0.40) | BRAFMAPK14GSK3ASRCSYK | |
| SCHEMBL1936142 | 0.90 | BRAF (0.42) | BRAFMAPK14GSK3ASRCSYK | |
| SCHEMBL15062934 | 0.89 | BRAF (0.43) | BRAFMAPK14GSK3ASRCSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331506-B1 | NOVEL BENZAMIDES, PRODUCTION THEREOF, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2013-07-03 | — | — | EP | disclosed |
| EP-2331506-A1 | NOVEL BENZAMIDES, PRODUCTION THEREOF, AND USE THEREOF AS MEDICAMENTS | Boehringer Ingelheim International GmbH (DE) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010026095-A1 | NOVEL BENZAMIDES, PRODUCTION THEREOF, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-11 | — | — | WO | disclosed |