Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 7/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 7/20 | 0.35 |
| ▸ | PIM1 | P11309 | 6/20 | 0.35 |
| ▸ | GPR6 | P46095 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618404 | 0.92 | TRPV1 (0.42) | PIM3PIM2PIM1GPR6TRPV1 | |
| SCHEMBL17618360 | 0.90 | GRM5 (0.37) | PIM3PIM2PIM1GPR6TRPV1 | |
| SCHEMBL16238183 | 0.89 | RPS6KB1 (0.39) | BTKMEN1KMT2A | |
| SCHEMBL17618459 | 0.89 | PIM2 (0.38) | PIM3PIM2PIM1TRPV1 | |
| SCHEMBL17618453 | 0.88 | GPR6 (0.39) | GPR6 | |
| SCHEMBL19670154 | 0.88 | PIM2 (0.34) | PIM3PIM2PIM1TRPV1ROCK2 | |
| SCHEMBL17618394 | 0.87 | TRPV1 (0.41) | PIM3PIM2PIM1GPR6TRPV1 | |
| SCHEMBL17618462 | 0.87 | ABL1 (0.41) | — | |
| SCHEMBL19699039 | 0.86 | HTR2C (0.46) | — | |
| SCHEMBL17618645 | 0.86 | GRM5 (0.40) | PIM3PIM2PIM1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |