Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | IDH2 | P48735 | 7/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17624590 | 1.00 | HTR2C (0.47) | HTR2CHTR2AIDH2KITKDM4E | |
| SCHEMBL16250014 | 1.00 | HTR2C (0.47) | HTR2CHTR2AIDH2KITKDM4E | |
| SCHEMBL17618354 | 0.95 | HTR2C (0.48) | HTR2CHTR2AIDH2KITMEN1 | |
| SCHEMBL17618622 | 0.92 | HTR2C (0.45) | HTR2CHTR2AIDH2MEN1KMT2A | |
| SCHEMBL17618371 | 0.92 | IDH2 (0.42) | IDH2KDM4EUSP2LMNAALOX15 | |
| SCHEMBL19365635 | 0.91 | IDH2 (0.42) | IDH2KDM4EUSP2LMNAALOX15 | |
| SCHEMBL17624591 | 0.91 | IDH2 (0.42) | IDH2KDM4EUSP2LMNAALOX15 | |
| SCHEMBL16249947 | 0.91 | IDH2 (0.42) | IDH2KDM4EUSP2LMNAALOX15 | |
| SCHEMBL16249974 | 0.90 | HTR2C (0.49) | HTR2CHTR2AIDH2KITTSHR | |
| SCHEMBL17618809 | 0.90 | HTR2C (0.45) | HTR2CHTR2AIDH2KITKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |