Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A2 | P31639 | 2/20 | 0.47 |
| ▸ | ALB | P02768 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 3/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | HTRA2 | O43464 | 4/20 | 0.43 |
| ▸ | HTRA1 | Q92743 | 4/20 | 0.43 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.41 |
| ▸ | OXTR | P30559 | 2/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21841338 | 0.94 | SLC5A2 (0.47) | SLC5A2ALBESR1BTKFOLH1 | |
| SCHEMBL19365740 | 0.91 | SLC5A2 (0.50) | SLC5A2ALBESR1BTKFOLH1 | |
| SCHEMBL19669062 | 0.88 | SLC5A2 (0.50) | SLC5A2ALBESR1BTKFOLH1 | |
| SCHEMBL16250025 | 0.88 | SLC5A2 (0.50) | SLC5A2ALBESR1BTKFOLH1 | |
| SCHEMBL19361190 | 0.87 | SLC5A2 (0.50) | SLC5A2ALBESR1BTKFOLH1 | |
| SCHEMBL19365750 | 0.82 | CA1 (0.53) | BTK | |
| SCHEMBL19365797 | 0.78 | TP53 (0.38) | HDAC3HDAC6 | |
| SCHEMBL19365748 | 0.75 | CA1 (0.51) | — | |
| SCHEMBL19669980 | 0.75 | CA1 (0.51) | — | |
| SCHEMBL19669056 | 0.74 | CA1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |