Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | IDH2 | P48735 | 5/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706298 | 0.90 | RHOA (0.38) | RHOACA2CA9CCR3IDH2 | |
| SCHEMBL17618881 | 0.89 | RHOA (0.40) | RHOACA2CA9CCR3IDH2 | |
| SCHEMBL17618882 | 0.88 | RHOA (0.42) | RHOACA2CA9CCR3IDH2 | |
| SCHEMBL16238714 | 0.87 | RHOA (0.43) | RHOACA2CA9IDH2SLC9A1 | |
| SCHEMBL16238473 | 0.85 | RHOA (0.38) | RHOACA2CA9CCR3IDH2 | |
| SCHEMBL16250011 | 0.84 | RHOA (0.48) | RHOACA2CA9CCR3IDH2 | |
| SCHEMBL19865069 | 0.84 | RHOA (0.48) | RHOACA2CA9CCR3IDH2 | |
| SCHEMBL16249983 | 0.84 | RHOA (0.48) | RHOACA2CA9CCR3IDH2 | |
| SCHEMBL17618756 | 0.84 | RHOA (0.41) | RHOACA2CA9IDH2MEN1 | |
| SCHEMBL17618883 | 0.84 | RHOA (0.40) | RHOACA2CA9CCR3IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |