Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.37 |
| ▸ | IDH2 | P48735 | 2/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16238714 | 0.95 | RHOA (0.43) | RHOACA2CA9BRD4CREBBP | |
| SCHEMBL16249975 | 0.95 | RHOA (0.48) | RHOACA2CA9BRD4CREBBP | |
| SCHEMBL16775763 | 0.91 | CREBBP (0.44) | RHOABRD4CREBBPNPY2RMEN1 | |
| SCHEMBL16250011 | 0.91 | RHOA (0.48) | RHOACA2CA9BRD4CREBBP | |
| SCHEMBL16249983 | 0.91 | RHOA (0.48) | RHOACA2CA9BRD4CREBBP | |
| SCHEMBL19865069 | 0.91 | RHOA (0.48) | RHOACA2CA9BRD4CREBBP | |
| SCHEMBL17618756 | 0.91 | RHOA (0.41) | RHOACA2CA9BRD4CREBBP | |
| SCHEMBL17624498 | 0.89 | RHOA (0.40) | RHOACA2CA9IDH2BRAF | |
| SCHEMBL16249976 | 0.89 | RHOA (0.39) | RHOACA2CA9IDH2NPY2R | |
| SCHEMBL16775765 | 0.87 | RHOA (0.44) | RHOABRD4CREBBPMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |