SCHEMBL19366148

SCHEMBL19366148

COC(=O)c1n[nH]c2c1COCC2

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 5/20 0.47
KDM4C Q9H3R0 1/20 0.45
WNT3A P56704 1/20 0.40
TNKS2 Q9H2K2 1/20 0.40
LRRK2 Q5S007 1/20 0.39
KMT2A Q03164 1/20 0.38
KDM4E B2RXH2 1/20 0.38
STAT3 P40763 1/20 0.38
HIF1A Q16665 1/20 0.38
TSHR P16473 1/20 0.37
AR P10275 1/20 0.37
NPC1 O15118 2/20 0.37
RAB9A P51151 2/20 0.37
NPSR1 Q6W5P4 1/20 0.36
GAA P10253 3/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
RXFP1 Q9HBX9 1/20 0.34
EP300 Q09472 1/20 0.34
CREBBP Q92793 1/20 0.34
CDK5 Q00535 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14487544 0.86 HCAR2 (0.65) HCAR2KDM4CLRRK2KMT2AKDM4E
SCHEMBL5951427 0.84 HCAR2 (0.44) HCAR2KMT2AKDM4EAR
SCHEMBL2849885 0.81 HCAR2 (0.72) HCAR2KMT2ATSHR
SCHEMBL30226021 0.80 HCAR2 (0.51) HCAR2KMT2ATSHRARNPC1
SCHEMBL30225969 0.78 HCAR2 (0.41) HCAR2KMT2AKDM4ETSHRAR
SCHEMBL24877853 0.78 HCAR2 (0.64) HCAR2KDM4CKMT2AKDM4ESTAT3
SCHEMBL1007395 0.78 HCAR2 (0.64) HCAR2KDM4CKMT2AKDM4ETSHR
SCHEMBL20541441 0.74 KDM4E (0.43) HCAR2KMT2AKDM4ETSHRNPC1
SCHEMBL5321007 0.73 HCAR2 (0.46) HCAR2KMT2ATSHRARNPC1
SCHEMBL16516621 0.72 HCAR2 (0.44) HCAR2KMT2AKDM4ETSHRNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4144739-A1 ANELLATED PYRAZOLES AS PARASITICIDES Bayer Aktiengesellschaft (DE) 2023-03-08 EP disclosed
WO-2017157992-A1 ANNULATED PYRAZOLES AS BUB1 KINASE INHIBITORS FOR TREATING PROLIFERATIVE DISORDERS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-09-21 WO disclosed