Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 8/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16147349 | 0.90 | FGFR1 (0.49) | FGFR1PTGER2SRCHTTCA2 | |
| SCHEMBL17531428 | 0.90 | FGFR1 (0.49) | FGFR1PTGER2SRCHTTCA2 | |
| SCHEMBL16147484 | 0.86 | FGFR1 (0.45) | FGFR1PTGER2SRCHTTCA2 | |
| SCHEMBL17531440 | 0.86 | FGFR1 (0.45) | FGFR1PTGER2SRCHTTCA2 | |
| SCHEMBL19067866 | 0.85 | FGFR1 (0.39) | FGFR1PTGER2HTTALDH1A1 | |
| SCHEMBL17531432 | 0.85 | FGFR1 (0.44) | FGFR1PTGER2SRCHTT | |
| SCHEMBL16148688 | 0.85 | FGFR1 (0.44) | FGFR1PTGER2SRCHTT | |
| SCHEMBL17531469 | 0.83 | FGFR1 (0.42) | FGFR1PTGER2SRC | |
| SCHEMBL16148304 | 0.83 | FGFR1 (0.42) | FGFR1PTGER2SRC | |
| SCHEMBL16147263 | 0.82 | FGFR1 (0.49) | FGFR1PTGER2SRCHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10617685-B2 | Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2020-04-14 | — | — | US | disclosed |
| US-20170266181-A1 | NONSTEROIDAL AND STEROIDAL COMPOUNDS WITH POTENT ANDROGEN RECEPTOR DOWN-REGULATION AND ANTI PROSTATE CANCER ACTIVITY | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10617685-B2 | Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity | AR, NR5A1, BRCA1 | FGFR1 1290/4885PTGER2 149/4885SRC 2254/4885 |
| US-20170266181-A1 | NONSTEROIDAL AND STEROIDAL COMPOUNDS WITH POTENT ANDROGEN RECEPTOR DOWN-REGULATION AND ANTI PROSTATE CANCER ACTIVITY | AR, NR5A1, BRCA1 | FGFR1 1290/4885PTGER2 149/4885SRC 2254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.