Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 20/20 | 0.81 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.81 |
| ▸ | SMC2 | O95347 | 1/20 | 0.81 |
| ▸ | EGFR | P00533 | 1/20 | 0.81 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.81 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.81 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.81 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.81 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.81 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | NQO2 | P16083 | 1/20 | 0.71 |
| ▸ | BRAF | P15056 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12957076 | 0.91 | MAP2K1 (0.81) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL569289 | 0.91 | MAP2K1 (0.84) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL13825413 | 0.91 | MAP2K1 (0.68) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL20439546 | 0.91 | MAP2K1 (0.84) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL29461531 | 0.91 | MAP2K1 (0.84) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL19141378 | 0.91 | MAP2K1 (0.86) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL18752730 | 0.90 | MAP2K1 (0.68) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL13825514 | 0.90 | MAP2K1 (0.67) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| Selumetinib SCHEMBL155456 | 0.90 | MAP2K1 (1.00) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| Selumetinib SCHEMBL29555068 | 0.90 | MAP2K1 (1.00) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305292-A1 | PHARMACEUTICAL COMPOSITION OF MEK INHIBITOR AND PREPARATION METHOD THEREOF | Chia Tai Tianqing Pharmaceutical Group Co.,Ltd (CN) | 2018-04-11 | — | — | EP | disclosed |
| WO-2017158499-A1 | OLIGOLACTIC ACID CONJUGATES AND MICELLES WITH ENHANCED ANTICANCER EFFICACY | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2017-09-21 | — | — | WO | disclosed |