Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 5/20 | 0.75 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.75 |
| ▸ | CDK2 | P24941 | 1/20 | 0.75 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.75 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.75 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.75 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.75 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.75 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.75 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.67 |
| ▸ | TSHR | P16473 | 5/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 5/20 | 0.55 |
| ▸ | CASP1 | P29466 | 3/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16854538 | 0.90 | NOTCH1 (0.81) | NOTCH1CCNA2CDK2PSEN1PSEN2 | |
| SCHEMBL16854567 | 0.90 | NOTCH1 (0.81) | NOTCH1CCNA2CDK2PSEN1PSEN2 | |
| SCHEMBL15538182 | 0.89 | NOTCH1 (0.79) | NOTCH1CCNA2CDK2PSEN1PSEN2 | |
| SCHEMBL16854539 | 0.88 | NOTCH1 (0.79) | NOTCH1CCNA2CDK2PSEN1PSEN2 | |
| SCHEMBL3325137 | 0.87 | NOTCH1 (0.76) | NOTCH1CCNA2CDK2PSEN1PSEN2 | |
| SCHEMBL16850575 | 0.87 | NOTCH1 (0.75) | NOTCH1CCNA2CDK2PSEN1PSEN2 | |
| SCHEMBL15537264 | 0.87 | NOTCH1 (0.80) | NOTCH1CCNA2CDK2PSEN1PSEN2 | |
| SCHEMBL16854540 | 0.87 | NOTCH1 (0.75) | NOTCH1CCNA2CDK2PSEN1PSEN2 | |
| SCHEMBL15537010 | 0.87 | NOTCH1 (0.75) | NOTCH1CCNA2CDK2PSEN1PSEN2 | |
| SCHEMBL3326628 | 0.87 | NOTCH1 (0.75) | NOTCH1CCNA2CDK2PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017157825-A1 | COMBINATIONS OF LSD1 INHIBITORS FOR USE IN THE TREATMENT OF SOLID TUMORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-09-21 | — | — | WO | disclosed |