Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | EP300 | Q09472 | 2/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.33 |
| ▸ | TEK | Q02763 | 2/20 | 0.33 |
| ▸ | CYBB | P04839 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17806206 | 0.80 | KDM1A (0.48) | CHRM1KDM1ACREBBPBRD4PRMT5 | |
| SCHEMBL17806353 | 0.76 | KDR (0.45) | CHRM1CHRM3EP300CREBBPS1PR1 | |
| SCHEMBL17806259 | 0.73 | KDM1A (0.49) | CHRM1KDM1ACREBBPBRD4 | |
| SCHEMBL17806217 | 0.73 | NOTUM (0.51) | KDM1AEP300CREBBPBRD4 | |
| SCHEMBL17806361 | 0.71 | CHRM1 (0.40) | CHRM1CHRM3CCNCCDK8BRD4 | |
| SCHEMBL17806327 | 0.68 | KDM1A (0.48) | KDM1AEP300CREBBP | |
| SCHEMBL17806220 | 0.67 | CCNC (0.40) | CHRM1CHRM3CCNCCDK8EP300 | |
| SCHEMBL19625615 | 0.67 | CHRM1 (0.37) | CHRM1CHRM3CCNCCDK8KDR | |
| SCHEMBL19675614 | 0.67 | HTR2C (0.37) | — | |
| SCHEMBL17806201 | 0.67 | CREBBP (0.50) | KDM1ACREBBPBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9763922-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2017-09-19 | — | — | US | disclosed |