Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BIRC2 | Q13490 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | XIAP | P98170 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14748128 | 1.00 | BIRC2 (0.34) | BIRC2DRD2DRD3CACNA2D1OPRM1 | |
| SCHEMBL3104025 | 1.00 | BIRC2 (0.34) | BIRC2DRD2DRD3CACNA2D1OPRM1 | |
| SCHEMBL18500378 | 0.82 | BIRC2 (0.35) | BIRC2CACNA2D1OPRM1HRH3 | |
| SCHEMBL10264751 | 0.82 | BIRC2 (0.35) | BIRC2CACNA2D1OPRM1HRH3 | |
| SCHEMBL10875701 | 0.81 | BIRC2 (0.33) | BIRC2HRH3XIAP | |
| SCHEMBL3106177 | 0.81 | CACNA2D1 (0.34) | DRD2DRD3CACNA2D1HRH3 | |
| SCHEMBL22222379 | 0.80 | CACNA2D1 (0.32) | CACNA2D1OPRM1 | |
| SCHEMBL3099099 | 0.79 | BIRC2 (0.34) | BIRC2CACNA2D1HRH3XIAP | |
| SCHEMBL2760223 | 0.79 | BIRC2 (0.34) | BIRC2CACNA2D1HRH3XIAP | |
| SCHEMBL12339303 | 0.79 | BIRC2 (0.34) | BIRC2CACNA2D1HRH3XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017161028-A1 | SUBSTITUTED INHIBITORS OF MENIN-MLL AND METHODS OF USE | KURA ONCOLOGY, INC. (US) | 2017-09-21 | — | — | WO | disclosed |