Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.38 |
| ▸ | IKZF3 | Q9UKT9 | 9/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.38 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | IL1B | P01584 | 1/20 | 0.38 |
| ▸ | MAP1LC3B | Q9GZQ8 | 4/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19359492 | 0.87 | CRBN (0.40) | CRBNBRD4MAP1LC3B | |
| SCHEMBL19370906 | 0.87 | CRBN (0.39) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL19370963 | 0.85 | CRBN (0.39) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL19370962 | 0.85 | CRBN (0.38) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL19370882 | 0.84 | CRBN (0.43) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL19370933 | 0.84 | CRBN (0.40) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL19370876 | 0.84 | HDAC1 (0.37) | CRBNIKZF3DDB1IKZF1BRD4 | |
| Hydrochloric Acid SCHEMBL19359319 | 0.83 | CRBN (0.54) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL19370897 | 0.82 | CRBN (0.40) | CRBNDDB1BRD4MAP1LC3B | |
| SCHEMBL19359345 | 0.76 | CRBN (0.43) | CRBNBRD4MAP1LC3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017161119-A1 | SMALL MOLECULES AGAINST CEREBLON TO ENHANCE EFFECTOR T CELL FUNCTION | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC. (US) | 2017-09-21 | — | — | WO | disclosed |