Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 9/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | RIPK3 | Q9Y572 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL477103 | 1.00 | CSNK1E (0.64) | CSNK1EALDH1A1CYP3A4HSD17B10HPGD | |
| SCHEMBL477104 | 1.00 | CSNK1E (0.64) | CSNK1EALDH1A1CYP3A4HSD17B10HPGD | |
| SCHEMBL477090 | 0.94 | CSNK1E (0.70) | CSNK1EALDH1A1CYP3A4HSD17B10HPGD | |
| SCHEMBL3115962 | 0.84 | CSNK1E (0.68) | CSNK1EALDH1A1CYP3A4HSD17B10HPGD | |
| SCHEMBL477141 | 0.84 | CSNK1E (0.55) | CSNK1EALDH1A1CYP3A4HSD17B10HPGD | |
| SCHEMBL3116565 | 0.81 | CSNK1E (0.68) | CSNK1EALDH1A1CYP3A4HSD17B10HPGD | |
| SCHEMBL3123892 | 0.80 | CSNK1E (0.64) | CSNK1EALDH1A1CYP3A4HSD17B10HPGD | |
| SCHEMBL477045 | 0.79 | CSNK1E (1.00) | CSNK1ERIPK3 | |
| SCHEMBL477139 | 0.79 | CSNK1E (0.67) | CSNK1ERIPK3 | |
| SCHEMBL3119961 | 0.79 | CSNK1E (0.65) | CSNK1ERIPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331546-A1 | 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-IB]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | Sanofi-aventis (FR) | 2011-06-15 | — | — | EP | disclosed |