Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1938014 | 1.00 | HDAC3 (0.41) | HDAC3MAPK1CNR2HTTSMN1; SMN2 | |
| SCHEMBL1937844 | 0.90 | HDAC3 (0.41) | HDAC3HTTSMN1; SMN2RXFP1LMNA | |
| SCHEMBL1937843 | 0.90 | HDAC3 (0.41) | HDAC3HTTSMN1; SMN2RXFP1LMNA | |
| SCHEMBL1937882 | 0.89 | HDAC3 (0.46) | HDAC3HTTSMN1; SMN2RXFP1LMNA | |
| SCHEMBL1937883 | 0.89 | HDAC3 (0.46) | HDAC3HTTSMN1; SMN2RXFP1LMNA | |
| SCHEMBL1937956 | 0.83 | HDAC3 (0.37) | HDAC3HTTSMN1; SMN2RXFP1LMNA | |
| SCHEMBL1938430 | 0.83 | HDAC3 (0.37) | HDAC3CNR2HTTSMN1; SMN2RXFP1 | |
| SCHEMBL1938431 | 0.83 | HDAC3 (0.37) | HDAC3CNR2HTTSMN1; SMN2RXFP1 | |
| SCHEMBL1937955 | 0.83 | HDAC3 (0.37) | HDAC3HTTSMN1; SMN2RXFP1LMNA | |
| SCHEMBL1938578 | 0.83 | HDAC3 (0.65) | HDAC3SMN1; SMN2LMNAPOLBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2330894-A1 | COMPOSITIONS INCLUDING 6-AMINOHEXANOIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010028192-A1 | COMPOSITIONS INCLUDING 6-AMINOHEXANOIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |